GHK-Cu serum vs injection for skin — my 8-week comparison
Been running GHK-Cu for 8 weeks — 4 weeks topical serum (2% in HA base) on left side of face, 4 weeks subQ injection (2mg/day) on right side. Then switched.
Topical results:
- Subtle texture improvement by week 3
- Pores slightly smoother
- No dramatic collagen changes visible
Injection results:
- Noticeable skin firmness by week 2
- Actual visible improvement in fine lines around eyes by week 4
- Skin "bounces back" differently
The injection route is clearly superior for actual structural changes. Topical works for surface-level texture but doesn't penetrate deep enough for real collagen remodeling.
This matches the published data. GHK-Cu topical penetration is limited to the upper dermis. SubQ gets systemic exposure. The 4,000+ gene modulation Pickart documented was at concentrations you can only achieve via injection.
Running the same experiment. Week 6 injectable side. Can confirm — the skin on that side literally feels different. Thicker, more elastic.
How are you guys sourcing your GHK-Cu? Prices vary wildly. I found it for $45 for 50mg from a supplier one of the peptide sites recommended. Same HPLC purity.